Biotechnology

What is Photoaging? How to treat it?

Photoaging

It’s a fact that we might not be able to stop the natural aging of our skin. However, there are certain interventions we can take control of and delay the onset of aging.

What is Skin?

Skin is deemed one of the largest organs in human bodies; as it takes more than fifty percent of the total body weight. Skin is having a plethora of functions; first, it is considered a physical barrier by which inward and outward of electrolytes, water, and other substances are controlled. Also, it acts as a defender for the human bodies against the external environment as well as harmful bacteria and other species.

What is Aging?

Aging in science can be defined as the breaking down of various physiological and chemical processes and components of the body that are important for survival and proper functioning.

The most-known causes of aging include; oxidative stress, degradation of telomerase and damage of mitochondrial genome.

What is Photoaging?

At many times, people are overly-exposed to the sunlight for many hours and even when they get older; different structural changes occur to the connective tissue. And the skin isn’t an exception; hence, the case is termed photo-aging.

The process starts when the collagen begins to break down, and the synthesis of the new collagen is blocked. In the skin dermis layer, collagen is present, and its primary function is to give the skin both strength and stability. And it also accounts for most of the skin dry weight.

Additionally, its secondary function is to resist the deformation happens to the skin. When people are getting older, skin starts to have a lack in the collagen fibers production resulting in the wrinkle formation afterward.

What are the Causes of Photoaging?

The leading cause of photoaging is a UV source, mostly through sunlight exposure. Other reasons include smoking that release carbon monoxide, thus, reduce blood flow and leave skin dry. Also, nanoparticle created as a result of combustion that destroys collagen and reduces the firmness of the skin. Moreover, genetics also play a significant role in the skin.

What are the Signs of Photoaging?

  • Fine lines and Wrinkles on the forehead
  • Development of Crow’s feet and circles on the sides of the eyes
  • The appearance of dark spot and freckles
  • Dehydrated and rough skin
  • Leathery skin
  • Pale color because of the damage of skins blood vessels.
  • Elastosis – commonly on the neck and chest area
Photoaging
Photoaging causing factors and their effects on the Skin.

Difference b/w Photoaging and Normal Aging

The differentiation b/w both is quite easy and straight forward. The normal aging exhibits a natural and predictable decrease in skin texture, elasticity, hydration, and even pigmentation. While the photoaging skin also follows almost the same symptoms but with earlier than the normal aging skin.

How Photoaging could be cured?

Carbon Dioxide Laser (CDL)

Out of the diverse methods used for treatment comes the carbon dioxide laser (CDL). Although the technique has proved positive results for skin rejuvenation, it showed numerous side effects such as redness, scarring, and peeling of skin.

β-carotene Topical Creams

Vitamin A plays a quite important role to keep skin and mucous membranes healthy. The beta carotene in the body act as a precursor of Vitamin A (retinol). The human body sourced Vitamin A from the food we eat, while beta carotene in a supplement form.

β-carotene Topical Creams include the beta carotene which is isolated from the carrots (Daucus carota). Although that method was efficient; side effects have been shown. Additionally, the therapeutic effect was taking too long to be noticed on patients.

Topical Creams made of Zinc-Oxide nanoparticles coated by Lycopene

A newly-innovated way to treat wrinkles and photo-aging. The idea is based on the production of ZnO nanoparticles and delivering them to target photo-aged cells after they have been coated by lycopene which has the therapeutic and medicinal effect.

By topical administration of the anti-aging cream and efficient treatment could be made using an antioxidant substance which is the lycopene and the ZnO nanoparticles. That can easily and efficiently penetrate the infected skin cells and cure them by producing their therapeutic effect.

Sunscreen

Sunscreen or sunblock contain sun protecting ingredients such as Helioplex and Mexoryl. Use sunscreen having at least Sun Protection Factor (SPF) 30 or even higher.

Ferulic Acid

A plant-based phenolic antioxidant that is potent and efficient and helps to reverse or heals sun causing damages on the skin.

Future Perspectives

Till now there are no specific drugs to totally cure the photo-aging or to completely stop/ reverse it. However, researchers are desperate to find a particular cure. Hopefully, they will find it in the next up-following few years.

Moreover, CRISPR gene-editing technology also shows potential to cure aging at the near upcoming future.

Explore More: Can CRISPR Gene-Editing Stop or Reverse Aging?

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